"Tetracycline, Oxytetracycline, And Chlortetracycline Determination By Flow Injection Potentiometry"
J. Pharm. Biomed. Anal.
1998 Volume 18, Issue 4-5 Pages 527-533
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Cristina M. C. M. Couto, José L. F. C. Lima, M. Conceição, B. S. M. Montenegro*, and Salette Reis
Abstract:
The determination of tetracycline (TCH), oxytetracycline (OTCH), and chlortetracycline (CTCH) by flow injection analysis system with potentiometric detection is described. In the flow system the drug samples were inserted in a carrier solution and converged with a Cu(NO3)2 solution of known concentration; the Cu(II) concentration decrease due to its complexation reaction with tetracyclines was monitored. The detector was a homogeneous crystalline CuS/Ag2S double membrane tubular electrode with increased sensitivity. The present system allows tetracyclines determination within concentration ranges of 48.1 - 4.8 x 10^3 ppm for TCH, 49.1 - 4.9 x 10^3 ppm for OTCH, and 51.5 - 5.1 x 10^3 ppm for CTCH and a precision better than 0.4% for the 3 drug species. This procedure capacity is 150-200 samples/h with a Cu(II) consumption of about 13 µg/determination. The method was tested on several commercial tetracycline preparations.
Tetracycline
Oxytetracycline
Chlorotetracycline
Pharmaceutical
Complexation
