University of North Florida
Browse the Citations
-OR-

Contact Info

Stuart Chalk, Ph.D.
Department of Chemistry
University of North Florida
Phone: 1-904-620-1938
Fax: 1-904-620-3535
Email: schalk@unf.edu
Website: @unf

View Stuart Chalk's profile on LinkedIn

Frank Michael Matysik

Abbrev:
Matysik, F.M.
Other Names:
Address:
Institute of Analytical Chemistry, University of Leipzig, Linnéstr. 3, 04103, Leipzig, Germany
Phone:
+49-341-9736103
Fax:
+49-341-9736107

Citations 7

"Capillary Electrophoresis And Capillary Flow Injection Analysis With Electrochemical Detection"
Fresenius J. Anal. Chem. 1996 Volume 356, Issue 3-4 Pages 169-172
F.-M. Matysik and Ulli Backofen

Abstract: The use of novel electrodes, viz. a spherical Au and a dual-microdisc, as electrochemical detectors for both capillary electrophoresis (CE) and FIA is presented. The detector consisted of a glass body equipped with a voltammetric Pt or carbon disk microelectrode with a conically-shaped tip, a Pt counter electrode and a Ag/AgCl reference electrode. The system was used for the simultaneous detection of hexacyanoferrate and hexacyano-osmate or ferrocene and nickelocene, using the capillary FIA technique. Separation of serotonin from its precursors and metabolites was effected with CE.
Electrophoresis

"Analytical Possibilities Of Microelectrode Use For Stripping Voltammetry"
Fresenius J. Anal. Chem. 1994 Volume 349, Issue 8-9 Pages 646-649
Frank-Michael Matysik Contact Information, Petra Gläser and Gerhard Werner

Abstract: A microelectrode capillary flow injection system (cf Matysik and Werner, Analyst (London), 1993, 118, 1523) was used to determine Pb2+ in 1.3 µL of water giving a linear calibration range of 10^-95 µg/l, a detection limit of 6 µg/l, and an RSD (n = 8) for 20 µg/l of Pb2+ of 3.2%. The use of hemispherical or disc Pt/Hg electrodes in anodic differential pulse stripping-voltammetric determination of 1 mg/l of Pb2+ in 1 mM HNO3 with deposition for 2 min at -1 V vs. Ag/AgCl, scan rate 10 mV/s and pulse amplitude 40 mV was studied. For 25-60 µm diameter disc micro-electrodes the RSD obtained without stirring during accumulation (0.38-0.76%) were lower than those obtained with stirring at 1000 or 2000 rpm (0.72-1.67%). The peak heights obtained using quiescent accumulation were significantly less than those obtained with stirring for larger electrodes but for micro-electrodes with diameter 30 µm these peak height differences were slight. The use of micro-electrodes to determine low µg/l levels of Cu2+ in whisky and Cd2+ and Pb2+ in drinking water is also described.
Cadmium(2+) Copper(II) Lead(2+) Whisky Water Voltammetry Electrode

"End-column Electrochemical Detection For Capillary Electrophoresis"
Electroanalysis 2000 Volume 12, Issue 17 Pages 1349-1355
Frank-Michael Matysik

Abstract: Amperometric and voltammetric techniques are very attractive for detection in capillary electrophoresis (CE). The low limits of detection attainable with capillary electrophoresis-electrochemical detection (CE-ED) are a definite advantage over the widely used on-column UV detection for CE. To fully exploit the potential of CE-ED and to make it accessible to the non-specialist, robust and user-friendly detector devices have to be developed. This article reviews recent advances in the field of end-column CE-ED which can be operated without the implementation of an electrical-field decoupler. Emphasis is given on the discussion of methodical aspects and on the design of decoupler-free detector configurations that are promising to enhance the practicality of CE-ED.

"Potentialities Of Electrochemical Detection In Conjunction With Non-aqueous Capillary Electrophoresis"
Electrochim. Acta 1998 Volume 43, Issue 23 Pages 3475-3482
Frank-Michael Matysika,*

Abstract: Electrochemical detection (ED) is applied to non-aqueous capillary electrophoresis (CE) performed in an acetonitrile buffer. The detection is based on a platinum microdisc electrode (d(Pt) = 25 µm) placed close to the capillary outlet of a 75 µm I.D. capillary. The CE-ED measurements can be performed without using an electrical-field decoupler owing to the reduced effect of the high voltage on the detection circuit when using the present detector configuration and non-aqueous separation buffers. The ED system is studied performing hydrodynamic voltammetry in the presence of electroosmotic flow. The exponent of flow rate dependence of the amperometric response is 0.68 for the present detector configuration. Practical applications of non-aqueous CE-ED concerning the analysis of dye substances such as malachite green, crystal violet, methylene blue, rhodamine B and morin are presented. In addition, some pharmaceutically relevant compounds are studied by CE-ED. In particular the capability of non-aqueous CE-ED for purity testing is discussed. By analyzing a 2 mM solution of trimethoprim it is possible to determine a content of 0.001% (2 x 10^-8 M) 2-amino-4-methylamino-5-(3,4,5-trimethoxybenzyl)pyrimidine which is a possible impurity of trimethoprim. No effects of electrode fouling were encountered during CE-ED experiments over measuring periods of several hours.
2-Amino-4-methylamino-5-(3-4-5-trimethoxybenzyl)pyrimidine Pharmaceutical Electrophoresis Amperometry Electrode Interface

"Voltammetric Characterization Of A Dual-disc Microelectrode In Stationary Solution"
Electrochim. Acta 1997 Volume 42, Issue 20-22 Pages 3113-3116
Frank-Michael Matysik

Abstract: The design and function of a dual-disc microelectrode device is described. The electrode assembly consists of two closely spaced platinum microdiscs sealed into a double-barrelled glass capillary. The practicality of the most common microelectrode geometry, ie the microdisc, is maintained also in the dual-disc configuration. The steady-state diffusion profiles do partially overlap each other. Thus, in analogy to the rotating ring-disc electrode generation-collection experiments can be performed, however, without the need of generated convection. At moderate scan rates (20 m V/s) no hysteresis occurs in the generation-collection mode. The dual-disc microelectrode system is characterized with respect to the collection efficiency, shielding and feedback factors using the ferrocene/ferrocenium couple. Furthermore, the reduction of Cu(II) in aqueous solution is studied by generation-collection experiments with the dual-disc microelectrode. (C) 1997 Published by Elsevier Science Ltd. 14 References
Ferrocene Electrode Electrode Voltammetry Apparatus Detector

"Electrochemically Assisted Injection - A New Approach For Hyphenation Of Electrochemistry With Capillary-based Separation Systems"
Electrochem. Commun. 2003 Volume 5, Issue 12 Pages 1021-1024
Frank-Michael Matysik

Abstract: A new concept based on the electrochemical conversion of analyte species during the injection into capillary flow systems is presented. This approach is termed electrochemically assisted injection (EAI). In a specially designed injection cell containing the analyte solution a conversion efficiency of about 83% can be achieved. Potassium octacyanotungstate(IV) served as a model compound for the analytical characterisation of EAI applying capillary flow injection analysis with double-pulse amperometric detection. Capillary electrophoresis experiments were performed using EAI to study the electrochemical oxidation of various ferrocene derivatives in acetonitrile solution. The electropherograms recorded with UV detection show separated signals for the ferrocene compounds and their oxidation products. The migration behavior and the stability of ferrocenium cations and other reaction products were investigated.

"Electrochemical Detection With Microelectrodes In Capillary Flow Systems"
Anal. Chim. Acta 1995 Volume 305, Issue 1-3 Pages 114-120
Frank-Michael Matysik*, Antje Meister and Gerhard Werner

Abstract: A novel electrochemical cell for capillary electrophoresis with end-column amperometric detection is described. A platinum microdisk electrode (dPt = 25 m) facing the capillary outlet served as sensing electrode. The problem of interference of the high voltage electrical field with the microelectrode circuit has been solved by the construction of a glass sleeve/Nafion joint for 100 m i.d. capillaries. With 25 m i.d. capillaries end-column detection could be performed without the use of an electrical-field decoupler arrangement. The analytical performance of the detector was characterized applying capillary zone electrophoresis and micellar electrokinetic capillary chromatography to separate various ferrocene derivatives. In addition, the same detector cell configuration has been used for amperometric detection in conjunction with capillary flow injection analysis.
Ferrocene Electrophoresis Amperometry Electrode Electrode Apparatus