University of North Florida
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Stuart Chalk, Ph.D.
Department of Chemistry
University of North Florida
Phone: 1-904-620-1938
Fax: 1-904-620-3535
Email: schalk@unf.edu
Website: @unf

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Xinrong Zhang

Abbrev:
Zhang, X.R.
Other Names:
Address:
Department of Chemistry, Tsinghua University, Beijing 100084, China
Phone:
+86-10-6277-0327
Fax:
+86-10-6278-7678

Citations 8

"Chemiluminescence Flow Injection Analysis Of 1,3-dichloro-5,5-dimethylhydantoin In Swimming Pool Water"
Talanta 2002 Volume 57, Issue 5 Pages 993-998
Zhiming Rao, Xinrong Zhang and Willy R. G. Baeyens

Abstract: A new chemiluminescence (CL) flow injection method is proposed for the determination of 1,3-dichloro-5,5-dimethylhydantoin (DDH). The method is based on the chemiluminescent reaction of DDH and luminol-H2O2 in an alkaline medium (pH 12.0-12.5). The concentration of the analyte shows a good linear relationship with the produced luminescence intensity in the range of 3.0 x 10^-8 to 8.0 x 10^-6 mol L-1. The detection limit of the proposed method is 1.0 x 10^-8 mol L-1 and the relative standard deviation (RSD) is 4.7% (n=5) at 5.0 x 10^-6 mol L-1. This method was successfully applied to the determination of trace amounts of this disinfectant in water samples obtained from five different swimming pools. Satisfying recovery values were also obtained. (C) 2002 Elsevier Science B.V. All rights reserved.

"Development Of A Luminol-based Chemiluminescence Flow Injection Method For The Determination Of Dichlorvos Pesticide"
Talanta 2001 Volume 54, Issue 6 Pages 1185-1193
Jianning Wang, Chao Zhang, Haixia Wang, Fengzhen Yang and Xinrong Zhang

Abstract: A simple, fast chemiluminescence (CL) flow injection method based on the reaction of luminol with H2O2 in the presence of a cationic surfactant (cyltrimethylammonium bromide, CTMAB) has been described for the direct determination of dichlorvos pesticide (DDVP). Under the optimal conditions, the CL intensity was linear to the DDVP concentration in the range of 0.02-3.1 µg mL-1 (r=0.9998, n=10). The relative standard deviation was 3.4% at 0.35 µg mL-1 (n=10), with a detection limit (3s) of 0.008 µg mL-1 DDVP. The possible reaction mechanism was also discussed. This method has been successfully applied to the determination of trace DDVP residue in vegetable sample and results have been compared with that of the UV method.

"A Novel Chemiluminescence Method For The Determination Of Orciprenaline Based On Ferricyanide-rhodamine 6G"
Luminescence 2005 Volume 20, Issue 4-5 Pages 298-302
Yi Lv, Rui Zhao, Zhenli Zhu, Xianshun Xu, Xinrong Zhang*

Abstract: A novel flow injection chemiluminescence method for the determination of orciprenaline was developed. The method is based on the chemiluminescence (CL) reaction of orciprenaline with potassium ferricyanide in sodium hydroxide medium, sensitized by the fluorescent dye rhodamine 6G. The proposed procedure allows quantitation of orciprenaline in the concentration range 0.01-1.2 µg/mL, with a detection limit of 7.2 x 10^-3 µg/mL. The relative standard deviation (RSD) is 2.7% for 0.1 µg/mL orciprenaline (n = 9). The sampling frequency was calculated at 120/h. The method was successfully applied to the determination of orciprenaline in pharmaceutical preparations. A brief discussion on the possible CL reaction mechanism is presented.

"Determination Of Ethamsylate In Pharmaceutical Preparations Based On An Auto-oxidation Chemiluminescence Reaction"
J. Pharm. Biomed. Anal. 2002 Volume 30, Issue 3 Pages 473-478
Fengzhen Yang, Chao Zhang, Willy R. G. Baeyens and Xinrong Zhang

Abstract: Strong chemiluminescence emission has been observed by mixing alkaline hydrolytic products of ethamsylate with Tween 80 in acidic rhodamine 6G solution. This phenomenon has been utilized to design a flow injection chemiluminescence method for the determination of ethamsylate in a pharmaceutical preparation. Under the optimum conditions, the proposed procedure has a linear range between 0.05 and 2.0 µg mL-1, with a detection limit of 0.02 µg mL-1 for ethamsylate. The method was applied to the determination of ethamsylate in pharmaceutical preparations. The possible mechanism of this chemiluminescence reaction was proposed. Copyright 2002 Elsevier Science B.V. [Journal Article; In English; England]

"Flow Injection Chemiluminescence Determination Of Fluoroquinolones"
Anal. Lett. 2000 Volume 33, Issue 6 Pages 1117-1129
Yi Rao; Yan Tong; Xinrong Zhang; Guoan Luo; Willy R. G. Baeyens

Abstract: A new flow injection CL method was developed for the determination of fluoroquinolones including ofloxacin, norfloxacin, ciprofloxacin and lomefloxacin in pharmaceutical preparations, based on the chemiluminescence reaction of sulfite with cerium(IV) sensitized by these compounds. The linear ranges are 0.04 to 4.0 µg mL-1 for ofloxacin and 0.4 to 40.0 µg mL-1 for norfloxacin, ciprofloxacin and lomefloxacin, respectively. The detection limits are 0.016 µg mL-1 for ofloxacin and 0.16 µg mL-1 for norfloxacin, ciprofloxacin and lomefloxacin, respectively. The relative standard deviations (RSD) are 2.1 to 2.6% (n = 10) for these fluoroquinolones. The analytical procedure has been applied to the determination of the fluoroquinolones in pharmaceutical commercial formulations. The results are in agreement with those obtained by the official methods.

"Microdialysis With On-line Chemiluminescence Detection For The Study Of Nitric Oxide Release In Rat Brain Following Traumatic Injury"
Anal. Chim. Acta 2001 Volume 428, Issue 2 Pages 173-181
Jianning Wang, Minqiang Lu, Fengzhen Yang, Xinrong Zhang, Willy R. G. Baeyens and A. M. García Campaña

Abstract: An on-line method was developed for the real-time detection of nitric oxide (NO) release in rat brain in vivo following traumatic injury by coupling microdialysis sampling to flow injection chemiluminescence (CL) detection. The NO released from rat cerebellum was detected based on the CL reaction of luminol and H2O2 with a detection limit of 1 nmol l-1. The perfusate flow was set at 5 µl min-1 in order to minimize NO loss before reaching CL detector. With this flow rate, about 5 s was required for the solution to pass through the membrane of microdialysis probe to the detector due to the dead volume of the probe and CL cell. It was observed that the efficiency of NO penetrated from rat cerebellum into perfusate stream increased along with decrease of perfusate flow rate. The maximum efficiency of 20% could be achieved at the flow rate of 5 µl min-1 with carefully home-made microdialysis probe. The developed method was applied to the study of the production of NO in rat cerebellum following the traumatic brain injury. The results indicated that the NO increased dramatically following traumatic brain injury and was inhibited after the injection of inhibitors such as -arginine.

"Determination Of Ofloxacin Using A Chemiluminescence Flow Injection Method"
Anal. Chim. Acta 2000 Volume 416, Issue 2 Pages 227-230
Yi Rao, Yan Tong, Xinrong Zhang, Guoan Luo and Willy R. G. Baeyens

Abstract: A new chemiluminescence (CL) flow injection method was proposed for the determination of ofloxacin in pharmaceuticals in the range 0.04-4 µg mL-1 with a detection limit of 0.016 µg mL-1 and a relative standard derivation (RSD) of 2.2% at 0.4 µg mL-1 (n=10). The method is based on the CL reaction of cerium(IV) with sulfite sensitized by ofloxacin. The established procedure could be applied to the determination of ofloxacin in tablet, capsule and injection in agreement with the results obtained by using reported methods.
Ofloxacin Pharmaceutical Pharmaceutical Pharmaceutical Chemiluminescence Method comparison

"Chemiluminescence Flow Injection Determination Of Furosemide Based On A Rhodamine 6G Sensitized Cerium(IV) Method"
Anal. Chim. Acta 1999 Volume 396, Issue 2-3 Pages 273-277
Y. Rao, Xinrong Zhang, Guoan Luo and Willy R. G. Baeyens

Abstract: A flow injection method is described for the determination of furosemide in the range 1.0-50.0 µmol L-1, with a detection Limit of 0.22 µmol L-1 and a relative standard deviation of 2.1% at 10 µmol L-1 (n = 10). The method is based on the chemiluminescence reaction of furosemide with cerium (IV) in sulfuric acid, sensitized by rhodamine 6G. By applying the method to tablets and injection solutions, it was found that the present method is relatively free from interference and tolerable to turbid solutions.