University of North Florida
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Stuart Chalk, Ph.D.
Department of Chemistry
University of North Florida
Phone: 1-904-620-1938
Fax: 1-904-620-3535
Website: @unf

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Classification: Pharmaceutical -> tablet -> coating

Citations 1

"Flow Injection Spectrophotometric Determination Of Phenothiazines Using Analyte Oxidation In Manganese-dioxide-packed Reactors"
Pharmazie 1998 Volume 53, Issue 3 Pages 168-172
Polásek, M.; Dolejsová, J.; Karlicek, R.

Abstract: A flow injection spectrophotometric method for determining 5 to 250 µg .cntdot. mL-1 of neuroleptic phenothiazines (namely prochlorperazine, thioridazine, levomepromazine, perphenazine, trifluoperazine and fluphenazine) using the analyte oxidation in manganese dioxide-packed reactors (50 mm x 1.2 mm) with aqueous 0.01 M sulfuric acid as carrier flow (0.6 mL .cntdot. min-1) has been devised. Active and stable reactor packings were prepared by coating sintered glass particles (diameter 0.4 to 0.5 mm) successively with an epoxide glue and powd. manganese dioxide or by thermal decomposition of Amberlite IRA-410 resin (20-50 mesh) in MnO4--form. At the injected sample volume of 100 pl the relative standard deviation was 1.2% (n = 10) when determining 75 µg .cntdot. mL-1 of prochlorperazine maleate in prepared solution of the pure substance and the sample throughput was 50 h-1. The method has been applied to the anal. of tablets and coated tablets containing prochlorperazine maleate, perphenazine, thioridazine hydrochloride or levomepromazine maleate. The results were in good agreement with those of the pharmacopoeial UV spectrophotometric determination.
Prochlorperazine Thioridazine Levomepromazine Perphenazine Trifluoperazine Fluphenazine Spectrophotometry Solid phase reagent Glass beads Amberlite Method comparison