University of North Florida
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Stuart Chalk, Ph.D.
Department of Chemistry
University of North Florida
Phone: 1-904-620-1938
Fax: 1-904-620-3535
Website: @unf

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Classification: Pharmaceutical -> lotion -> eye

Citations 2

"Flow Injection Analysis Of Cobalt(II) Utilizing Enhanced Lophine Chemiluminescence With Hydroxylammonium Chloride"
Biomed. Chromatogr. 1997 Volume 11, Issue 2 Pages 63-64
Kenichiro Nakashima*, Hiromi Yamasaki, Ryo Shimoda, Naotaka Kuroda, Shuzo Akiyama, Willy R. G. Baeyens

Abstract: A rapid and convenient flow injection method is described for the determination of Co(II). The method utilized the phenomenon that the lophine-Co(II)-H2O2 chemiluminescence (CL) reaction Is enhanced in alkaline media by the addition of hydroxylammonium chloride. The calibration curve was linear over the range 2 x 10^-7 to 2 x 10^-5 M with a detection limit of 4.5 x 10^-8 M (0.9 pmol) at a signal-to-noise ratio of 2. The method was applied to the assay of cyanocobalamin in commercially available eye lotions. (C) 1997 by John whey and Sons, Ltd. 4 References
Cobalt(II) Vitamin B12 Chemiluminescence Indirect

"Flow Injection Analysis Of Tetracyclines Using Inhibited Ru(bpy)32+/tripropylamine Electrochemiluminescence System"
Luminescence 2005 Volume 20, Issue 1 Pages 8-15
Yong-Qiang Pang, Hua Cui*, Hai-Song Zheng, Guo-Hui Wan, Li-Juan Liu, Xiao-Feng Yu

Abstract: Tetracyclines (TCs) were found to strongly inhibit the electrochemiluminescence (ECL) from the Ru(bpy)32+-tripropylamine system when a working Pt electrode was maintained at 1.05 V (vs. Ag/AgCl) in pH 8.0 carbonate buffer solution. On this basis, a flow injection (FI) procedure with inhibited electrochemiluminescence detection has been developed for the determination of tetracycline (TC) and oxytetracycline (OTC). Under the optimized condition, the linear ranges of 2.0 x 10^-8-1.0 x 10^-5 and 1.0 x 10^-8-1.0 x 10^-5 g/mL and the detection limits of 4.0 x 10^-9 and 3.8 x 10^-9 g/mL were obtained for TC and OTC, respectively. The relative standard deviations (RSD) were 0.68% and 1.18% for 5.0 x 10^-7 g/mL TC and OTC (n = 13), respectively. The method showed higher sensitivity than most of the reported methods. It was successfully applied to the determination of tetracycline in a Chinese proprietary medicine, Tetracyclini and Cortisone Eye Ointment, and the residues of tetracycline in honey products. The inhibition mechanism has been proposed due to an energy transfer between electrogenerated Ru(bpy)32+* and benzoquinone derivatives at the electrode surface.
Tetracycline Chemiluminescence Electrode Optimization Sensitivity