University of North Florida
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Stuart Chalk, Ph.D.
Department of Chemistry
University of North Florida
Phone: 1-904-620-1938
Fax: 1-904-620-3535
Website: @unf

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Classification: Pharmaceutical -> lotion

Citations 1

"Automated Flow Injection Determination Of Salicylates Using Trinder Reaction For Clinical Analysis, Assays And Dissolution Studies Of Formulations"
J. Pharm. Biomed. Anal. 1988 Volume 6, Issue 1 Pages 35-46
M. A. Koupparis* and P. I. Anagnostopoulou

Abstract: The construction and use of a flow injection analyzer. with absorbance measurement at 540 nm is described. Salicylate(I), salicylamide(II) and methyl salicylate(III), as well as aspirin after alkaline hydrolysis, were determined by reaction with Fe(III) in weakly acidic medium (0.02 M HNO3). The method has been applied to tablets (and lotions) for determination of 25 to 250 or 80 to 800 mg L-1 of I, 30 to 300 mg L-1 of II and 100 to 1000 mg L-1 of III. It was suitable for dissolution tests. The method was also applied to determine I in serum. Recovery was 96.4 to 103.0% and coefficient of variation were <1%. Interference was much reduced compared with that affecting the manual Trinder method.
Salicylate Methylsalicylate Salicylamide Aspirin Clinical analysis Spectrophotometry Dissolution rate Interferences Method comparison