University of North Florida
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Stuart Chalk, Ph.D.
Department of Chemistry
University of North Florida
Phone: 1-904-620-1938
Fax: 1-904-620-3535
Website: @unf

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Classification: Pharmaceutical -> gel -> dental

Citations 2

"Determination Of Tin(II) In Pharmaceuticals By Amperometric Oxidation After Complexation With Tropolone"
Electroanalysis 1996 Volume 8, Issue 8-9 Pages 789-794
K. Boutakhrit, G. Quarin, S. A. Özkan, J.-M. Kauffmann *

Abstract: Dental gel (2 g) was extracted with hot 1 M HCl (20 ml) by sonication for 5 min, and a portion of the extract was diluted with 50 mM acetate buffer of pH 5.5 containing 0.1 mM tropolone. A 20 µL portion of the mixture was injected into an FIA system comprising 50 mM acetate buffer of pH 5.5 as the carrier solution. The solution was pumped (0.8 ml/min) through a reaction coil (30 cm x 0.2 mm i.d.) to an electrochemical cell equipped with a vitreous-carbon working electrode, an Ag/AgCl reference electrode and a Pt-wire counter electrode. The working electrode potential was set at +0.1 V. The response was linear over the range 0.25-20 µM, and the detection limit was 0.1 µM. None of the cations investigated interfered. Interference caused by some organic compounds usually present in radiopharmaceutical preparations is reported.
Tin(II) Amperometry Electrode Sample preparation Interferences Buffer Complexation

"Spectrophotometric Determination Of Fluoride In Dosage Forms And Dental Preparations"
J. Pharm. Biomed. Anal. 1996 Volume 14, Issue 8-10 Pages 951-958
R. Sandulescu*, E. Florean, L. Roman, S. Mirel, R. Oprean and P. Suciu

Abstract: The method is based upon the reaction between fluoride ions and the colored complex of Fe(III) with methyl salicylate to form the stable, colorless hexafluoride complex of iron. The conditions of the method (pH, time and combination ratio) were studied and a standard curve was obtained for 0.01-0.08 mg NaF mL-1, at 525 nm. A study was conducted on interference with complexing anions of Fe(III), cations that react with fluoride ions and with common ingredients of dosage forms and dental preparations. The method was validated and the results showed good precision (100.16±2.33%) comparable with that of other analytical methods. Good results were obtained in the spectrophotometric determination of fluoride ions in a stomatological gel and in a toothpaste.
Fluoride Iron Spectrophotometry Complexation Method comparison Interferences