University of North Florida
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Stuart Chalk, Ph.D.
Department of Chemistry
University of North Florida
Phone: 1-904-620-1938
Fax: 1-904-620-3535
Website: @unf

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Classification: Pharmaceutical -> drop -> oral

Citations 1

"Determination Of Papaverine And Cocaine By Use Of A Precipitation System Coupled Online To An Atomic Absorption Spectrometer"
J. Pharm. Biomed. Anal. 1994 Volume 12, Issue 2 Pages 179-184
Marcelina Eisman, Mercedes Gallego and Miguel Varcarcel*

Abstract: In the reversed flow injection system (diagram given) incorporating an AAS instrument operated at 357.9 nm, portions (30 µL) of the precipitating reagent, aqueous 0.2% (for papaverine; I) or 0.25% (for cocaine; II) Reinecke's salt of pH 5, was injected into a stream (3.3 ml/min) of 10 mM HCl and passed through a reaction coil (130 cm x 0.5 mm i.d.) producing a high Cr peak. Samples of I or II in 10 mM HCl were then continuously pumped into the system and another injection of Reinecke's salt produced a precipitate which was retained on the filter producing a low peak. The difference between the two peaks represented the amount of precipitated Cr (proportional to the drug concentration). The calibration graphs were linear from 5-85 µg/ml of I and 50-850 µg/ml of II; the corresponding detection limits were 2 and 25 µg/ml and the corresponding RSD were 1.3% and 3.2%. Sample throughput was 150/h. Tolerated amounts of foreign drugs are tabulated. The method was applied to powdered tablets (0.4 or 3 g), oral drops (0.8 ml), syrup (20 ml) and an ampoule of injectable solution dissolved in 100 or 250 mL of H2O.
Papaverine hydrochloride Drugs Spectrophotometry Precipitation Reverse