University of North Florida
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Stuart Chalk, Ph.D.
Department of Chemistry
University of North Florida
Phone: 1-904-620-1938
Fax: 1-904-620-3535
Website: @unf

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Classification: Pharmaceutical -> dragee

Citations 2

"Application Of Automated Flow Injection Analysis To Drug Liberations Studies With The Franz Diffusion Cell"
Pharmazie 2001 Volume 56, Issue 10 Pages 787-789
Solich, P.; Ogrocká, E.; Schaefer, U.

Abstract: The flow-injection method with sensitive fluorimetric detection is used to monitor the liberation profiles of a topical dermatological formulation containing the model compound salicylic acid. The connection of a standard Franz diffusion cell with the automated flow-injection system enables an acquisition of multi-point liberation data in a form of series of fluorescence peaks in a short time. Examples of liberation profiles for a topical dermatological formulation containing salicylic acid are shown.
Salicylic acid Fluorescence Interface

"Quinine Determination In Some Mass Produced Pharmaceuticals By Flow Injection Analysis With Fluorimetric Detection"
Cesk. Farm. 1987 Volume 36, Issue 5 Pages 201-206
Polasek, M.;Karlicek, R.;Solich, P.

Abstract: Portions (120 µL) of a solution of quinine sulfate in 0.05 M H2SO4 were injected in a carrier stream of water (1.5 mL min-1), and the fluorescence of the solution was measured at 415 nm (excitation at 365 nm) in a flow cell (volume 2 to 8 µL). Response was rectilinear for 0.05 to 0.3 or 0.5 to 3.0 µg mL-1 of quinine sulfate. The method was applied to dragees and tablets. The coefficient of variation was <1.3% (n = 3).
Quinine Fluorescence Review