University of North Florida
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Stuart Chalk, Ph.D.
Department of Chemistry
University of North Florida
Phone: 1-904-620-1938
Fax: 1-904-620-3535
Website: @unf

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Organic compound

Classification: Organic compound -> hydroxynitrile

Citations 1

"Micellar Enhanced Cyanide Ion Determination In Samples From Synthetic Organic Processes"
Talanta 1997 Volume 44, Issue 7 Pages 1203-1209
John O. Egekeze*, Thomas M. Dowling, Nelu Grinberg, Holly J. Perpall and Gary R. Bicker

Abstract: Liquid hydroxynitrile concentrate (0.5 ml) from a cyanation reaction between NaCN and an organic sulfite was diluted to 100 mL with 1 mM cetyltrimethylammonium bromide (CTAB) in 0.05 M NaOH [for samples in 5% DMF in isopropylacetate (IPAC) or aqueous samples] or with 2 mM CTAB in 0.05 M NaOH (for samples in 12% DMF in toluene). To determine cyanide, a portion (10 µL) was injected into a stream (1.5 ml/min) of 0.044 M Chloramine T in phosphate buffer of pH 7, which merged with a stream (0.5 ml/min) of 0.375 M barbituric acid in pyridine/HCl. The flow passed through a reaction coil (15 m x 0.5 mm i.d.) and the absorbance was measured at 578 nm. Recoveries of cyanide were 93.2% from DMF/IPAC and 93.9% from DMF/toluene. Calibration graphs were linear for 0.25-5 ppm in 2 mM alkaline CTAB and 0.25-10 ppm in 1 mM alkaline CTAB. The detection limits were 0.1 ppm and RSD were 1.8-2.1% (n = 6). Sample throughput was 40/h.
Cyanide Sample preparation Spectrophotometry Micelle