University of North Florida
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Stuart Chalk, Ph.D.
Department of Chemistry
University of North Florida
Phone: 1-904-620-1938
Fax: 1-904-620-3535
Website: @unf

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Classification: Biological fluid -> urine -> rabbit

Citations 1

"Online Monitoring Of Nitrofurantoin In Urine Of Rabbit By A Flow Injection System With A Fiber-optic Chemical Sensor"
Yaoxue Xuebao 1995 Volume 30, Issue 8 Pages 599-604
Li, W.;Chen, J.

Abstract: A flow injection system for monitoring of nitrofurantoin (NFT) in rabbit urine that makes use of a kind of fiber-optic chemical sensor is presented. The NFT-sensitive optrode was combined with a membrane onto which was immobilized pyrenebutyric acid (PBA) as a fluoriprobe. The NFT concentration was determined via dynamic quenching of the fluorescence of PBA. The average recovery was 96.5%-102.9%. The relative standard deviations for within-day and between-day were 3.1%-3.7% and 1.6%-3.8% respectively. The calibration curve was linear in the range from 2 µg mL-1 to 100 µg mL-1 with r = 0.9983. The detection limit of this method was 0.74 µg mL-1. The urine drug concentration-time course in rabbit after oral administration conformed to a one compartment open model with a first order absorption phase. Mean T1/2 value was 0.75±0.14 h. The selectivity was affirmed by HPTLC.
Nitrofurantoin Fluorescence Optrode Sensor Sensor Indirect Method comparison Optical fiber Quenching