Abstract: An automated system with polarographic or spectrophotometric detection was developed for the serial anal. of pharmaceutical samples. As models for testing the analyzer, four preparations, Prodectin, Eunoctin, Seduxen and Verospiron containing pyridinol carbamate [1882-26-4], nitrazepam [146-22-5], diazepam [439-14-5] and spironolactone [52-01-7], respectively, were used. All 4 compounds had useful UV absorption and, with the exception of spironolactone, were also polarographically active at the Hg electrode. In polarographic determination, the problems associated with deaeration were overcome by using N bubbling. A peristaltic pump was designed for feeding N continuously, which after a sufficient time, eliminated oxygen completely. The spectrophotometric device differed from the polarographic one in that a flow-through detector preceded the peristaltic pump. A sampling rate of 120/h was achieved with the flow-cell. The methods are reproducible, sensitive and accurate. The relative standard deviation for polarographic and spectrochemical analysis were 1.13-1.35% and 0.14%, respectively. (SFS)