University of North Florida
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Stuart Chalk, Ph.D.
Department of Chemistry
University of North Florida
Phone: 1-904-620-1938
Fax: 1-904-620-3535
Email: schalk@unf.edu
Website: @unf

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Trends in Biotechnology

  • Publisher: Elsevier
  • FAD Code: TRBT
  • CODEN: TRBIDM
  • ISSN: 0167-7799
  • Abbreviation: Trends Biotechnol.
  • DOI Prefix: 10.1016/j.tibtech,10.1016/S0167-7799
  • Language: English
  • Comments: Fulltext from 1983 V1

Citations 7

"The Development And Applications Of Thermal Biosensors For Bioprocess Monitoring"
Trends Biotechnol. 1999 Volume 17, Issue 12 Pages 499-505
Kumaran Ramanathan, Morten Rank, Juraj Svitel, Anatoli Dzgoev and Bengt Danielsson

Abstract: Enzyme thermistors are biosensors that use thermal resistors to measure the heat change caused by an enzymatic reaction. They combine the selectivity of enzymes with the sensitivity of biosensors and allow continuous analysis in a flow injection mode. They can be used to monitor fermentation systems, biocatalysis, enzyme-catalyzed synthesis and clinical and food technology. This article gives an overview of the general principles of enzyme thermistors, the sampling process and the ongoing developments in the field of bioprocess monitoring.
Apparatus Automation Catalysis

"Automation Of Functional Assays By Flow Injection Fluorescence Microscopy"
Trends Biotechnol. 1999 Volume 17, Issue 11 Pages 443-447
Louis D. Scampavia, Peter S. Hodder, Ilkka Lähdesmäki and Jaromir Ruzicka

Abstract: Bead-injection spectroscopy is a novel technique that uses immobilized eukaryotic cells on microbeads as a renewable biosensor for fluorescence microscopy. The use of a flow injection instrument allows fast functional assays that generate full kinetic characterization of a drug. Because the cell population is automatically replaced for each assay, Variability is minimized, thus allowing greater accuracy.
Automation

"Online And In-situ Monitoring Of Biomass In Submerged Cultivations"
Trends Biotechnol. 1997 Volume 15, Issue 12 Pages 517-522
Lisbeth Olsson and Jens Nielsen

Abstract: Biomass is one of the most important variables in submerged-cultivation processes and, in recent years, many different sensors have been introduced for online or in situ monitoring of this variable. This article provides an overview of the principles behind these sensors and discusses their application in both laboratory and industrial processes. 34 References
Biomass Fermentation broth Fluorescence Sensor Review

"Automation Of Selective Assays For Online Bioprocess Monitoring By Flow Injection Analysis"
Trends Biotechnol. 1996 Volume 14, Issue 12 Pages 471-477
Jens J. van der Pol, Cornelis D. de Gooijer, Manfred Biselli, Christian Wandrey and Johannes Tramper

Abstract: Online analysis of one component in a complex media used for bioprocesses requires the application of selective tests such as enzymes assays. Because these assays are susceptible to interference by other medium components and have a limited detection range, automatic sample pretreatment is a prerequisite. The progress made with automatic sample pretreatment in flow injection analysis makes this technique particularly suitable for online monitoring of bioprocesses. Moreover, newly developed software control systems may improve the necessary robustness of flow-infection analysis systems.
Biotechnology Interferences Process monitoring

"Challenges In Integrating Biosensors And FIA For Online Monitoring And Control"
Trends Biotechnol. 1996 Volume 14, Issue 1 Pages 21-31
Karl Schügerl, Bernd Hitzmann, Heike Jurgens, Thomas Kullick, Roland Ulber and Beate Weigal

Abstract: Several obstacles prevent the increased use of biosensors in industrial bioprocess monitoring and control. Among these are the absence of robust and reliable biosensors with the required specificity and sensitivity for use in complex media, and the absence of adequate sampling techniques. Progress with the integration of amperometric and potentiometric biosensors into flow injection analysis (FIA) systems may provide a route to developing automated, reliable, on-line systems for bioprocess control.
Sensor Review Process control Process monitoring

"Sensors As Components Of Integrated Analytical Systems"
Trends Biotechnol. 1994 Volume 12, Issue 2 Pages 42-46
Thomas Scheper,Frank Plötz, Cord Müller and Bernd Hitzmann

Abstract: This paper focuses on the construction of a simple optical sensor system for the determination of penicillin V in a culture of Penicillium chrysogenum. This example illustrates problems that are representative of those encountered in the installation and optimization of sensors in complex analytical systems used for continuous monitoring of relevant bioprocess variables and, thus, should illustrate the requirements for the development of a successful, integrated sensor system.
Penicillin Pharmaceutical Sensor Review

"What’s Cooking? Optimizing Bioprocess Monitoring"
Trends Biotechnol. 1992 Volume 10, Issue 7 Pages 230-232
Michael J. Geisow

Abstract: Biotechnology products derived from microbial, eukaryotic cell, and even whole plant and animal systems are increasing sharply in number. The scale (e.g. fermenter size) and complexity (e.g. glycoprotcins from hollow-fiber cell culture) of products arc also increasing. Such cultures demand close, interactive monitoring. This is needed not only to preclude serious economic losses from large-scale cultures, but also to ensure that product quality is consistent (e.g. in glycoprotcins produced from mammalian cell culture).
Fermentation broth HPLC Optimization Process monitoring