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Stuart Chalk, Ph.D.
Department of Chemistry
University of North Florida
Phone: 1-904-620-1938
Fax: 1-904-620-3535
Email: schalk@unf.edu
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Ceskoslovenska Farmacie

  • Publisher:
  • FAD Code: CEFM
  • CODEN: CSLFEK
  • ISSN: 0009-0530
  • Abbreviation: Cesk. Farm.
  • DOI Prefix: NA
  • Other Name(s): Ceska a Slovenska Farmacie, Czechoslovakian Pharmacy
  • Language: Czech
  • Comments: Abstracts from 1999

Citations 9

"Oxidative Determination Of Rutine In Tablets By The Method Of Flow Injection Analysis With Chemiluminescence Detection"
Cesk. Farm. 2004 Volume 53, Issue 3 Pages 145-150
DolejŠová J., PolÁŠek M., Solich P., KarlíČek R., TŮmová L.

Abstract: A simple, rapid and fully automated flow injection method (FIA) with chemiluminescence detection after oxidation with KMnO4 in acid medium at room temperature has been developed for the determination of rutine in pharmaceutical formulation. Hexamethaphosphate sodium was utilized as enhancer of chemiluminescence. The calibration curve was linear in the range 0.01-0.26 mmol.l-1 with detection limit 0.005 mmol.l-1, RSD 0.46% (n=10) and a sample throughput of 75.h-1 using a 200 µL sample volume. The method was used for the determination of rutine in mass-produced dosage form: Rutin 250 tablets a? 50 mg, (firm Nature's Bounty, USA). The FIA method was statistically compared with the official German Pharmacopoeia method and showed comparable accuracy, but with the advantages of simplicity, speed and amounts of reagents consumed.

"Improvement Of Amperometric Detection (AD) By Determination Of Drugs By Flow Injection Methods-flow Injection Analysis (FIA) And Sequential Injection Analysis (SIA)"
Cesk. Farm. 2001 Volume 50, Issue 3 Pages 107-112
PAPUGOVÁ P., POLÁČEK M.

Abstract: The present review dealing with the use of various electrochemical detection systems in flow methods of analysis of drugs (such as FIA and SIA techniques). The review covers the period of 1988 to 1998 and involves 78 references. The drugs determined are arranged according to the functional groups undergoing electrochemical transformation; for all the analytes data on the detection conditions, detection limits and ranges of quantitation are included. Advantages and drawbacks of amperometric detection of drugs in flow systems are discussed.

"Oxidative Determination Of Hydroxyamphetamine In Drops By The Method Of Flow Injection Analysis"
Cesk. Farm. 2000 Volume 49, Issue 4 Pages 199-202
DOLEJŠOVÁ J., KARLÍČEK R., POSPÍŠILOVÁ M.

Abstract: A flow injection-spectrophotometric determination at 540 nm of hydroxyamphetamine is reported. The procedure is based on a colored reaction with 2-hydrazono-3-methylbenzothiazole (MBTH) and ceric ammonium nitrate (Ce(IV)) as the oxidation reagent. Under optimized conditions, the determination of hydroxyamphetamine is achieved in a range of 0.01-0.2 mmol.l-1 with a relative standard deviation of 0.78 % for 0.05 mmol.l-1 (n=10) and a sample throughput of 75.h-1. The method was used for the determination of medicinal drug in the mass-produced dosage form of Czech origin: Pedrolon drops, Galena a.c.

"Trends In The Development And Application Of Flow Injection Analysis (FIA) In Pharmaceutical Analysis"
Cesk. Farm. 1992 Volume 41, Issue 2 Pages 62-68
Karlicek, R.;Solich, P.

Abstract: A review with 108 references discussing applications of flow injection analysis of pharmaceuticals in combination with chemiluminescence, fluorimetry, spectrophotometry, amperometry, and volumetry.
Pharmaceutical Chemiluminescence Fluorescence Spectrophotometry Amperometry Review Titrations

"Hydroxylaminolysis Of β-lactams And Its Use For The Determination Of Penicillins By Flow Injection Analysis"
Cesk. Farm. 1990 Volume 39, Issue 2 Pages 77-79
Karlicek, R.;Solich, P.

Abstract: A three-stream (0.6 mL min-1 each) system was used, containing three coils in series, of length 25, 50 and 100 cm (A, B and C, respectively). A sample (85 µL) was injected into a stream of reagent solution of pH 6.2 composed of 0.1 M hydroxylammonium chloride and 0.15% Brij-35 in aqueous 25% ethanol, the mixture was passed through reaction coil A (for hydrolysis of β-lactam rings), then acidified to pH ~1 by mixing with a stream of 0.5 M H2SO4 in coil B, merged with solution comprising 12.8 g of (NH4)2Fe(SO4)2 and 1 mL of 15% Brij-35 in 100 mL of 0.05 M H2SO4 - ethanol (3:1), and passed through coil C. The absorbance of the colored complex formed with Fe(III) was measured at 505 nm. Calibration graphs were rectilinear for 0.25 to 3 mg mL-1 of ampicillin, benzylpenicillin, procaine penicillin or phenoxymethylpenicillin, and the detection limits were ~0.1 mg mL-1. The coefficient of variation (n = 6 to 10) were 1.5% for ~1 mg mL-1 of individual penicillins. The method is suitable for analysis of pharmaceuticals; throughput is 50 h-1.
Penicillins Ampicillin Benzylpenicillin Penicillin procaine Phenoxymethylpenicillin Pharmaceutical Spectrophotometry pH Calibration

"Fluorimetric Determination Of Ergotamine In Medicinal Preparations By Flow Injection Analysis"
Cesk. Farm. 1989 Volume 38, Issue 1 Pages 1-5
Polasek, M.;Solich, P.;Karlicek, R.

Abstract: Samples (~100 µL) of ergotamine tartrate (I) solution in aqueous 2% tartaric acid were injected into a carrier stream of water (1.1 mL min-1) at up to 70 samples h-1. Detection was by fluorimetry at 415 nm (excitation at 325 nm). The calibration graph was rectilinear for 0.1 to 15 µg mL-1 of I. I was determined in tablets (0.3 to 1 mg) and in drops (0.25 mg mL-1). The coefficient of variation was 1.8% (n = 3). Caffeine (100-fold excess) and phenobarbitone (saturated solution in aqueous 2% tartaric acid) interfered.
Ergotamine tartrate Pharmaceutical Fluorescence Interferences

"Quinine Determination In Some Mass Produced Pharmaceuticals By Flow Injection Analysis With Fluorimetric Detection"
Cesk. Farm. 1987 Volume 36, Issue 5 Pages 201-206
Polasek, M.;Karlicek, R.;Solich, P.

Abstract: Portions (120 µL) of a solution of quinine sulfate in 0.05 M H2SO4 were injected in a carrier stream of water (1.5 mL min-1), and the fluorescence of the solution was measured at 415 nm (excitation at 365 nm) in a flow cell (volume 2 to 8 µL). Response was rectilinear for 0.05 to 0.3 or 0.5 to 3.0 µg mL-1 of quinine sulfate. The method was applied to dragees and tablets. The coefficient of variation was <1.3% (n = 3).
Quinine Pharmaceutical Pharmaceutical Fluorescence Review

"Specific Detection And Determination Of Aminophenazone By Oxidative Coupling With Phenol"
Cesk. Farm. 1985 Volume 34, Issue 5 Pages 168-173
Fraenkl, M.;Svobodova, D.;Karlicek, R.

Abstract: Amidopyrine is oxidized to 4-aminoantipyrine, which is coupled oxidatively with phenol to form a red product; ammoniacal buffer medium of pH 7.5 to 8.5 and K3Fe(CN)6 as oxidant are used. The qualitative test is sensitive (~1 ppm), and no other common drug reacts in this way. Spectrophotometric measurement (at 510 nm) gives a rectilinear calibration graph for 0.04 to 0.4 mM amidopyrine. In the determination of amidopyrine in different medicaments, the coefficient of variation were <0.5%. Other methods of determination, viz, that involving oxidation by vanadate or titration of the base in acetic acid medium, give less reliable results. Up to 120 samples containing 10 to 100 ppm of 4-aminoantipyrine can be analyzed in 1 h by flow injection analysis based on the described reaction.
Amidopyrine Aminophenazone Spectrophotometry

"Flow Injection Analysis And Its Use In Drug Analysis"
Cesk. Farm. 1982 Volume 31, Issue 5 Pages 190-192
Karlicek, R.

Abstract: NA
Drugs Pharmaceutical