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Stuart Chalk, Ph.D.
Department of Chemistry
University of North Florida
Phone: 1-904-620-1938
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Yaowu Fenxi Zazhi

  • Publisher: Wanfang Data
  • FAD Code: YFZZ
  • CODEN: YFZADL
  • ISSN: 0254-1793
  • Abbreviation: Yaowu Fenxi Zazhi
  • DOI Prefix: NA
  • Other Name(s): Chinese Journal of Pharmaceutical Analysis
  • Language: Chinese
  • Comments: Fulltext not available

Citations 17

"Flow Injection Determination Of Prednisone Acetate"
Yaowu Fenxi Zazhi 1998 Volume 18, Issue 3 Pages 168-170
Liang Yaodong,Li Jianzhong and Zhang Zhujun, Zhang Xiaoqing

Abstract: Based on the enhancement of chemiluminescence reaction of prednisone acetate on the cerium IV and sulfite system, a flow injection chemiluminescence method was developed for determination of prednisone acetate. Linear range was 0.2-20.0 mg/L, detection limit was 0.031 mg/L, and RSD was 1.8 in 11 parallel determinations in the sample concentration. of 0.2 mg/L. The method was used in determination of prednisone acetate in tablets with good results.
Prednisone acetate Pharmaceutical Chemiluminescence Indirect

"Study On Chemiluminescence System Of Potassium Permanganate/levodopa In Assay Of Levodopa"
Yaowu Fenxi Zazhi 1998 Volume 18, Issue 1 Pages 41-45
Yang Minli, Li Liqing, Feng Manliang and Lu Jiuru

Abstract: A sample solution was diluted with water to 25 mL and then analyzed by FIA (diagram given). The sample mixed with streams of 0.05 M KMnO4 and 1 M H6P4O13 in the flow injection system and the chemiluminescence thus generated was measured. The calibration graph for levodopa (dopa) was linear from 0.4-80 mg/l and the detection limit was 62 g/l. The method was also used to analyze tablets; RSD were 1.6%. The results were compared with those obtained by UV spectrophotometry. None of the investigated co-existing components interfered. The FIA sample throughput was 120/h. In this paper,a new chemiluminescence system of potassium permanganate-levodopa was investigated and a new chemiluminescence method for the determination of levodopa with flow injection technique was established. The concentration range of linear response is 4 x 10^-4~8 x 10^-2g/L.The detection limit is 6.2 x 10^-5g/L with a relative standard deviation of 1.6% for the determination of 4 x 10^-3g/L of levodopa(n=11). The method has been used to determine the content of levodopa in tablets with satisfactory results.
Levodopa Pharmaceutical Chemiluminescence Interferences

"Chemiluminescence Determination Of Sodium Nitroprusside By Flow Injection Analysis"
Yaowu Fenxi Zazhi 1997 Volume 17, Issue 2 Pages 75-77
Li Jianzhong, Wang Tieling

Abstract: Sample was dissolved in 0.5 mL 2 M NaOH and diluted with water to 25 mL. After 1 min, a 100 µL portion of the solution was injected into the flow injection manifold (diagram shown) into a stream of NaHCO3/Na2CO3 buffer of pH 12 and mixed with reagent streams of 1 mM luminol and 50 mM H2O2 pumped at 3 ml/min and the chemiluminescence intensity was measured. The calibration graph for sodium nitroprusside (I) was linear from 0.2 µM to 0.1 mM with a detection limit of 9 nM. Copper(II), oxalate and ascorbic acid interfered. Sampling frequency was 40 runs per h. The method was applied to the analysis injection solutions containing I, with recovery of 98.5-101% and RSD of 1-1.2%. Results agreed closely with those obtained by the method published in the Chinese Pharmacopoeia.
Nitroprusside Pharmaceutical Chemiluminescence Method comparison Interferences Standard method

"Determination Of The Solubility Of Minocycline Capsules By Flow Injection Analysis"
Yaowu Fenxi Zazhi 1996 Volume 16, Issue 5 Pages 341-342
Feng, W.Y.;Luo, J.;Zhang, S.H.

Abstract: Six capsules were agitated in 900 mL water by the rotating basket method. Portions (2 ml) of the solution were withdrawn at various times, filtered and diluted. Prepared samples (30 µL) were injected into a carrier stream of 0.01 M HCl which merged with a chromogenic stream of 5% FeCl3 then passed through a reaction coil (130 cm long) prior to detection at 450 nm. The calibration graph was linear from 50-250 units/ml. The recovery was 99.8% with a RSD of 0.98%. Results were compared with those obtained by HPLC. Up to 95.6% of minocycline capsules were dissolved within 45 min. The sampling frequency was 150 /h.
Minocycline Pharmaceutical Spectrophotometry

"Flow Injection Analysis - Spectrophotometric Determination Of Vitamins B1 And B2 In Multi-formulation Vitamin Preparations"
Yaowu Fenxi Zazhi 1996 Volume 16, Issue 3 Pages 184-186
Yang, J.M.;Chang, H.

Abstract: Powdered sample, containing 4 mg vitamin B1 (thiamine; I), was stirred with 12 mL 0.1 M HCl for 20 min to dissolve and then shaken with 6 mL diethyl ether for 1 min; the aqueous layer was collected and diluted to 50 mL with water. A portion (10 ml) of the solution was treated with 5% KMnO4 to pink then with 10% NaNO2 to discharge color before dilution with water to 25 mL. A 140 µL portion of the solution was injected into a a carrier stream of water (0.94 ml/min) of a flow injection analyzer. (schematic shown) and mixed with reagent streams of 3.1 mM p-aminobenzenesulfonic acid diazo salt (0.5 ml/min) and 0.5 M NaOH/0.34 M Na2CO3 (0.73 ml/min) in a reactor (158 cm x 0.7 mm i.d.) and the colored product of I formed was detected at 520 nm. For the determination of vitamin B2 (riboflavine; II), the sample was injected in a similar manner but with water being used in place of the reagent streams and detection was at 440 nm. Calibration graphs were linear up to 100 and 80 µg/ml, respectively, for I and II. Recoveries were 95-101%. Results were comparable with those obtained by fluorescence spectrophotometry and LC. No interference from excipients was observed.
Thiamine Riboflavine Pharmaceutical Spectrophotometry Interferences

"Flow Injection Spectrophotometric Method For The Determination Of Vitamin B6"
Yaowu Fenxi Zazhi 1994 Volume 14, Issue 3 Pages 14-16
Liu Wanzhong, Wang Chaodong, Chen Hao

Abstract: Sample was dissolved in 50% ethanol to a concentration of 30 µg/ml of vitamin B6 (I) and then 200 µL of the solution was injected into the FIA system and carried at 1.5 ml/min by a stream of 50% ethanol to mix with streams of 20% sodium acetate and 0.5% chloroimino-2,6-dichloroquinone in 50% ethanol in a reaction tube (400 cm x 0.8 mm i.d.) before detection at 650 nm. Calibration graphs were linear for 3-60 µg/ml of I. Only tetracyclines and phenols interfered. Recovery was 99.7% with RSD of 0.8%. The method was applied to the assay of single- and compound-formulated I tablets. The sampling frequency was 150 runs per h.
Vitamin B6 Pharmaceutical Spectrophotometry Interferences

"Derivatization Techniques In Conjunction With HPLC For Pharmaceutical Analysis"
Yaowu Fenxi Zazhi 1992 Volume 12, Issue 4 Pages 243-248
Ding, L.X.;Ni, K.Y.

Abstract: A review is presented, with 113 references, of various methods of derivatization, and includes discussion on pre- and post-column derivatization and a comparison of these procedures (with extensive tabulation of practical examples).
Pharmaceutical HPLC Post-column derivatization Review

"Determination Of Clonidine In Its Preparations By Solvent Extraction - Flow Injection Analysis"
Yaowu Fenxi Zazhi 1992 Volume 12, Issue 3 Pages 135-138
Liu, W.Z.;Chen, H.

Abstract: A sample of clonidine hydrochloride (I) tablets (equivalent to ~0.5 mg of I) was dissolved in and diluted with Na2HPO4 - citric acid buffer (pH 4) to 100 mL. After centrifugation, 150 µL of the solution was injected into the flow injection apparatus (diagram illustrated) with water as carrier (2 mL min-1) then reacted with a reagent stream of bromophenol blue in the above buffer (2 mL min-1). The resulting ion associate flows to the extraction tube (2.5 m x 0.7 mm), is extracted with CHCl3 (2.5 mL min-1) and I is detected at 413 nm. The calibration graph was rectilinear for 15 to 70 µg mL-1 of I, the detection limit was 0.2 µg mL-1 and the coefficient of variation was 0.85%. Average recovery was 100.4%.
Clonidine Pharmaceutical Spectrophotometry Sample preparation Ion pair extraction Organic phase detection Solvent extraction

"Rapid Determination Of Ascorbic Acid In Pharmaceuticals By Flow Injection Spectrophotometry"
Yaowu Fenxi Zazhi 1992 Volume 12, Issue 1 Pages 26-28
Ma, Y.;Yang, J.

Abstract: A method for the determination of ascorbic acid (I) in pharmaceuticals by flow injection spectrophotometry is described. The method is based on the reaction of I with a mixture of Fe3+ and 1,10-phenanthroline in pH 2 to 6 HCl medium to form a colored complex; the absorbance of the complex is then measured at 510 nm (ε = 12,000). Beer's law was obeyed for 1 to 12 µg mL-1 of I and the coefficient of variation (n = 12) was 0.27%.
Ascorbic acid Pharmaceutical Spectrophotometry Complexation Indirect

"Studies On Flow Injection Analysis Of Phenytoin Sodium Using A Sensor"
Yaowu Fenxi Zazhi 1991 Volume 11, Issue 4 Pages 199-202
Liu, W.Z.;Zuo, A.L.

Abstract: To detect the phenytoin (I) - hexadecyltrioctylammonium ion-pair complex, the I-sensitive flow-through sensor is of i.d. 0.7 to 1.0 mm and thickness 0.1 mm, and the volume between the sensor and the sampling valve is ~50 µL. The peak heights for both I standard solution (0.5 to 10 mM) and sample solution (1 mM in 0.1 M borate) are measured with a carrier flow rate of 3 mL min-1, a sample size of 400 µL and a sampling rate of 60 to 120 h-1 at pH 9.5 to 10.5. The calibration graph is rectilinear from 0.03 to 10 mM I. The recovery was 99.4% (n = 10) with a coefficient of variation of 0.8%. The results agreed with those by a pharmacopoeial method.
Phenytoin Potentiometry Sensor Method comparison Ion pair formation

"Flow Injection Ion-selective Electrode For Quinine"
Yaowu Fenxi Zazhi 1990 Volume 10, Issue 5 Pages 261-264
Liu, W.Z.;Yan, Z.

Abstract: A description is given of a flow-through sensor for the determination of quinine by flow injection analysis. The sensor exhibits Nernstian response over the range 10 µM to 10 mM quinine at pH 5 to 8; only benzalkonium bromide and diphenhydramine interfere seriously. For an injection volume of 300 µL and use of 0.1 M NaCl as carrier, the average recovery was 100.7% with a coefficient of variation of 1.2%. Results were comparable with those obtained by the method of the Chin. P. The analysis rate is up to 120 h-1.
Quinine Electrode pH Interferences Standard method

"Study Of Flow Injection Analysis Chemiluminescence System Of 3,5-dibromosalicylfluorone - Hexadecyltrimethylammonium Bromide - Hydrogen Peroxide - Cobalt(II) And Determination Of Trace Cobalt(II) In Vitamin B12 [cyanocobalamin]"
Yaowu Fenxi Zazhi 1990 Volume 10, Issue 1 Pages 26-28
Li, G.H.;Li, M.;Zhang, W.G.

Abstract: Optimum conditions involved 0.15 mM 3,5-dibromosalicylfluorone, 15 mM hexadecyltrimethylammonium bromide, 0.2 M H2O2 and 0.1 M NaOH, and flow rates of 6.4 mL min-1. The calibration graph was rectilinear for 0.5 to 200 ng mL-1 of Co(II). The detection limit was 0.3 ng mL-1, and the coefficient of variation was 0.9%.
Cobalt(II) B12 Chemiluminescence Detection limit Optimization

"Preparation Of Tubular Flow-through Atropinium Sensor And Its Application In A Flow Injection System"
Yaowu Fenxi Zazhi 1989 Volume 9, Issue 6 Pages 347-350
Cui, H.B.;Sun, J.Y.;Li, B.;Zhang, Z.;Fang, Y.

Abstract: The cited ion-selective electrode is prepared by applying a solution containing 1% of atropine - tetraphenylboric acid ion associate, 68% of dibutyl phthalate and 31% of PVC powder in THF to a PVC tube (35 mm x 1 mm) with a 1.5-mm hole in the middle (diagram given). To determine atropine sulfate (I), ground tablets (300 mg) are mixed with 0.1 M Mg acetate to 50 ml, the solution is filtered and a 1 mL portion is further diluted with 0.1 M Mg acetate to a known volume A 300 µL aliquot of the solution is carried by a 0.1 M Mg acetate stream to the electrode in a flow injection analyzer.. Recovery was 98 to 101% and the coefficient of variation was 1.2%. Results agreed closely with those of the Chin. P. The electrode has a life-span of over 1 year.
Atropine sulfate Pharmaceutical Electrode Electrode Sensor Method comparison

"Determination Of An-fu-ming 11S Injection By HPLC - Post-column Derivatization"
Yaowu Fenxi Zazhi 1988 Volume 8, Issue 5 Pages 308-310
Zhong, P.

Abstract: A 1 mL injection sample (containing Thr, Gly, Val, Met, Ile, Leu, Phe, Lys, His and Arg) is diluted to 100 mL with 0.2N-Na citrate solution (pH 2.2) and then 1 mL of the solution is mixed with 1 mL of glutamic acid (100 µg mL-1; internal standard) and 0.2N-Na citrate to 10 mL. A 25 µL portion of solution is analyzed by HPLC on an ISC-07/S1540 strongly acidic ion-exchange column (15 cm x 4 mm) operated at 55°C with gradient elution (0.5 mL min-1) from 0.2N-Na citrate (pH 3.25) to 0.6N-Na citrate (pH 9). The eluate is passed (0.6 mL min-1) through a pre-heated (55°C) coil (60 cm x 0.3 mm) in which the amino-acids react with phthalaldehyde for 2.5 s. The derivatives are detected fluorimetrically. Recoveries are 98.2 to 102.3% and the coefficient of variation (n = 4) are 0.3 to 1.9%. No pre-treatment is required. The method is simple and accurate, with good reproducibility.
Threonine Glycine Valine Methionine Isoleucine Leucine Phenylalanine Lysine Histidine Arginine HPLC Fluorescence Heated reaction Post-column derivatization

"Flow Injection Analysis And Its Applications In Pharmaceutical Analysis"
Yaowu Fenxi Zazhi 1988 Volume 8, Issue 4 Pages 248-250
Ma, G.;Jiang, D.

Abstract: A review is presented in which the basic principles of flow injection analysis are described and its applications in pharmaceutical analysis are discussed, including determination of impurities in pharmaceuticals and of drugs in body fluids. (64 references).
Drugs Pharmaceutical Review

"Studies Of Determination Of Compound Amino-acid Injections By Post-column Derivatization HPLC"
Yaowu Fenxi Zazhi 1987 Volume 7, Issue 5 Pages 267-270
Zhou, Y.

Abstract: The amino-acids in 20 µL samples of compound amino-acid injections or branched-chain amino-acid injections or compound glutamic acid capsules were separated by HPLC on a strongly acidic cation-exchange resin column (15 cm x 4 mm) with 0.2 M Na citrate (pH 3.25 and 4.25) and 0.6 M Na citrate (pH 8.33) as mobile phases at 0.5 mL min-1 in the cited order but varying the time for each mobile phase as appropriate. After derivatization with phthalaldehyde, fluorescence detection was at 490 nm (excitation at 370 nm). Recovery averaged 99.74%, and the coefficient of variation was 2.02% (n = 109). Derivatives of 15 amino-acids (Asp, Thr, Ser, Glu, Gly, Ala, Val, Met, Ile, Leu, Tyr, Phe, His, Lys and Arg) were determined in the eight compound amino-acid preparations; however, the method failed to detect tryptophan and proline. The method was simple, rapid, sensitive and had good reproducibility.
Amino Acids HPLC Fluorescence Post-column derivatization

"Recent Advances In Water Determination"
Yaowu Fenxi Zazhi 1984 Volume 4, Issue 2 Pages 120-124
Ma, G.

Abstract: A review is presented, with 23 references, of methods published during the last decade. The methods considered include(I) modifications of the Karl Fischer technique by use of, e.g., coulometric generation of the reagent, flow injection analysis or, for water in solids, kinetic methods;(II) g.c. and HPLC; (iii) coulometry; (iv) n.m.r.; (v) thermometric titration; and (vi) miscellaneous methods applicable to specific materials, e.g., kinetic spectrophotometry, polarography and thermogravimetry.
Water Karl Fischer analysis Kinetic Review