University of North Florida
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Stuart Chalk, Ph.D.
Department of Chemistry
University of North Florida
Phone: 1-904-620-1938
Fax: 1-904-620-3535
Email: schalk@unf.edu
Website: @unf

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Thiabendazole

  • IUPAC Name: 4-(1H-benzimidazol-2-yl)-1,3-thiazole
  • Molecular Formula: C10H7N3S
  • CAS Registry Number: 148-79-8
  • InChI: InChI=1S/C10H7N3S/c1-2-4-8-7(3-1)12-10(13-8)9-5-14-6-11-9/h1-6H,(H,12,13)
  • InChI Key: WJCNZQLZVWNLKY-UHFFFAOYSA-N

@ ChemSpider@ NIST@ PubChem

Citations 5

"Sequential Injection Analysis For The Determination Of Fuberidazole And Thiabendazole By Variable-angle Scanning Fluorescence Spectrometry"
Anal. Chim. Acta 2001 Volume 427, Issue 1 Pages 83-92
G. de Armas, E. Becerra, A. Cladera, J. M. Estela and V. Cerdà

Abstract: A study of the behavior of fuberidazole (FBZ) (2-(2-furyl)benzimidazole), and thiabendazole (TBZ) (2-(thiazol-4-yl)benzimidazoie) in a sequential injection system with a fluorimetric detector has been performed. Several variables such as pH, composition of buffers, volumes of sample and reagents, addition order, geometry of mixing coil and spectrofluorimetric parameters have been optimized. A pH 2 buffer solution was found to be optimal for both FBZ and TBZ. The calibration graphs are linear between 0.04 and 10 µg L-1 for FBZ and between 0.08 and 20 µg L-1 for TBZ with 3s detection limits of 0.012 and 0.02 µg L-1, respectively. The relative standard deviation (n = 10) was 0.3% for 1 µg L-1 of FBZ and 0.5% for 2 µg L-1 of TBZ. Resolution of the system was carried out by applying a multiple linear regression (MLR) calibration model. The method was applied to the determination of both fungicides added to natural waters. Recoveries between 96 and 106% were achieved.
Water Mineral Fluorescence Sequential injection Multivariate calibration Optimization

"Simultaneous Determination Of Fluorophores With Overlapped Spectra By Sequential Injection Analysis Coupled To Variable Angle Scanning Fluorescence Spectrometry And Multivariate Linear Regression Algorithms"
Anal. Chim. Acta 2002 Volume 471, Issue 2 Pages 173-186
Graciela de Armas, Manuel Miró, José Manuel Estela and Víctor Cerdà

Abstract: An automated and versatile sequential injection spectrofluorimetric procedure for the simultaneous determination of multicomponent mixtures in micellar medium without prior separation processes is reported. The methodology is based upon the segmentation of a sample slug between two different buffer zones in order to attain both an improvement of sensitivity and residual minimization for the whole species. Resolution of overlapping fluorescence profiles is achieved using a variable angle scanning technique coupled to multivariate least-squares regression (MLR) algorithms at both sample edges. The potentialities of the described methodology are illustrated with the spectrofluorimetric determination of four widespread pesticides with different acid-base properties; viz. carbaryl (CBL) (1-naphthyl-N-methylcarbamate), fuberidazole (FBZ) (2-(2-furyl)benzimidazole), thiabendazole (TBZ) (2-(4-thiazolyl)benzimidazole) and warfarin (W) (3-α-acetonylbenzyl)-4-hydroxycoumarin. Detection limits at the 3s level were 3.9, 0.02, 0.03 and 10 µg L-1 for CBL, FBZ, TBZ and W, respectively at the maximum sensitivity pH. Dynamic ranges of 13-720 µg L-1 CBL, 0.10-14 µg L-1 FBZ, 0.19-60 µg L-1 TBZ and 0.05-5 mg L-1 W were achieved. Relative standard deviations (n = 10) were 0.2% for 100 µg L-1 CBL and 2.4 µg L-1 FBZ, 0.7% for 8 µg L-1 TBZ and 1.0% for 1 mg L-1 W. The proposed automated methodology, which handles 17 samples/h, was validated and applied to spiked real water samples with very satisfactory results. (C) 2002 Elsevier Science B.V. All rights reserved.
Water Mineral Fluorescence Multivariate calibration Sequential injection Simultaneous analysis Automation Micelle

"Flow Injection Analysis Of Pharmaceutical Compounds. 7. Determination Of Some Anthelmintic And Antiprotozoal Compounds"
Spectrosc. Lett. 1996 Volume 29, Issue 2 Pages 299-319
M. Y. Mohamed; A. E. El-Gendy; M. G. El-Bardicy; M. S. Tawakkol; A. K. S. Ahmad

Abstract: The ethanolic sample solution (24 µL) prepared from tablets or suspensions is injected into a carrier stream of ethanol and the absorbance is measured in an 80 µL flow cell with a pathlength of 1 cm; wavelengths, flow rates (usually 2.2 ml/min) and other parameters are tabulated for the determination of diloxanide furoate, flubendazole, mebendazole, metronidazole, oxamniquine, thiabendazole and tinidazole. Calibration graphs were linear for 2-14 µg/ml for all these drugs except thiabendazole and tinidazole (1-12 and 4-16 µg/ml, respectively). Good recoveries are demonstrated.
Pharmaceutical Spectrophotometry

"Continuous-flow Separation And Pre-concentration Coupled On-line To Solid-surface Fluorescence Spectroscopy For The Simultaneous Determination Of o-phenylphenol And Thiabendazole"
Anal. Bioanal. Chem. 2004 Volume 378, Issue 2 Pages 429-437
J. F. García Reyes, E. J. Llorent Martínez, P. Ortega Barrales and A. Molina Díaz

Abstract: A novel and single flow-injection system combined with solid-surface fluorescence detection is proposed in this work for the resolution of a mixture of two widely used pesticides (o-phenylphenol and thiabendazole). The continuous-flow methodology is based on the implementation of on-line pre-concentration and separation of both analytes on the surface of C18 silica gel beads placed just inside the flow cell, implemented with gel-phase fluorimetric multi-wavelength detection (using 305/358 and 250/345 nm as excitation/emission wavelengths for thiabendazole and o-phenylphenol, respectively). The separation of the pesticides was possible owing to the different retention/desorption kinetics of their interactions with the solid support in the zone where the stream impinges on the solid material. No previous separation of the analytes before they reach the flow cell is needed thereby simplifying substantially both the procedure and the manifold. By using a sample volume of 2,600 µL, the system was calibrated in the range 0.5-16 and 5-120 ng mL-1 with detection limits of 0.09 and 0.60 ng mL-1 for thiabendazole and o-phenylphenol, respectively. The RSD values (n=10) were about 1% for both analytes. The proposed methodology was applied to environmental water samples and also to various commercial pesticide formulations containing both analytes. Recovery percentages were 97-103% and 98-102% for thiabendazole and o-phenylphenol, respectively.

"Sequential Injection Analysis Applied To The Simultaneous Fluorimetric Multiresidue Determination"
Luminescence 2002 Volume 17, Issue 4 Pages 259-260
Graciela de Armas, Manuel Miro, Jose Manuel Estela and Victor Cerda

Abstract: A stopped-flow sequential injection (SI) spectrofluorimetric procedure is presented for the simultaneous on-line determination of Carbaryl (CBL) (1-naphthyl-N-methylcarbamate), Fuberidazole (FBZ) (2-(2 -furyl)-benzimidazole), Thiabendazole (TBZ) (2-(4 -thiazolyl)-benzimidazole) and Warfarin (W) (3-α-acetonylbenzyl)-4-hydroxycoumarin) (Fig. 1) in micellar medium through the chemometric resolution of the recorded variable angle scanning (VAS) spectra.
Environmental Fluorescence Sequential injection Chemometrics Stopped-flow Optimization