University of North Florida
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Stuart Chalk, Ph.D.
Department of Chemistry
University of North Florida
Phone: 1-904-620-1938
Fax: 1-904-620-3535
Email: schalk@unf.edu
Website: @unf

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Sorbitol

  • IUPAC Name: (2R,3R,4R,5S)-hexane-1,2,3,4,5,6-hexol
  • Molecular Formula: C6H14O6
  • CAS Registry Number: 50-70-4
  • InChI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2
  • InChI Key: FBPFZTCFMRRESA-JGWLITMVSA-N

@ ChemSpider@ NIST@ PubChem

Citations 5

"Amperometric Detection Of Simple Carbohydrates At Platinum Electrodes In Alkaline Solutions By Application Of A Triple-pulse Potential Waveform"
Anal. Chim. Acta 1981 Volume 132, Issue 1 Pages 11-22
Scott Hughes and Dennis C. Johnson

Abstract: The response of ten simple carbohydrates was investigated voltammetrically at platinum electrodes in 0.10 M sodium hydroxide by application of a conventional linear sweep waveform and a triple-pulse waveform. Linear-sweep data were interpreted to suggest that electrochemical reactions of the carbohydrates involve oxidation of adsorbed hydrogen atoms produced by surface-catalyzed dehydrogenation of the adsorbed carbohydrate. The triple-pulse measurement technique was evaluated for a flow-injection system by introducing 100-l samples into a stream of 0.1 M NaOH with a flow rate of 0.375 mL min-1, and measuring the peak current. Peak currents for ten carbohydrates at 0.5 mM ranged from 17 to 42 a and a detection limit of 0.01 mM was evaluated for dextrose. Calibration plots of reciprocal peak current (I-1p) vs. reciprocal of concentration (C-1) were linear for dextrose and sorbitol concentrations between 0.1 and 1.0 mM.
Amperometry Electrode Potentiometry Catalysis

"Nickel Oxide Dispersed In A Graphite/poly(vinyl Chloride) Composite Matrix For An Electrocatalytic Amperometric Sensor For Alditols In Flow Injection Analysis"
Anal. Chim. Acta 1995 Volume 307, Issue 1 Pages 43-48
Tommaso R. I. Cataldi* and Diego Centonze

Abstract: A chemically modified electrode was prepared with 50% NiO, 7% PVC and graphite and packing the mixture into a PTFE cavity (4 mm i.d.). The electrode was used in a FIA system for the amperometric detection of alditols. The wall-jet detection cell also had a Ag/AgCl(3 M KCl) reference electrode and a stainless-steel auxiliary electrode; the working electrode was maintained at +0.5 V. The carrier electrolyte (0.5 ml/min) was 0.1 M NaOH and the sample injection volume was 50 µL. Calibration graphs were linear up to 50 mM alditol (or 25 mM sorbitol) and detection limits were 0.02 M for sorbitol, myo-inositol and xylitol, 0.05 M for dulcitol, 0.08 M for mannitol and 0.1 M for D-arabitol. The RSD for 0.5 mM of analyte were 0.8-1.5% (n = 4-6). The performance of the electrode was stable over 72 h.
Amperometry Electrode Electrode Sensor Catalysis Flowcell

"Copper Dispersed Into Polyaniline Films As An Amperometric Sensor In Alkaline Solutions Of Amino-acids And Polyhydric Compounds"
Anal. Chim. Acta 1996 Volume 335, Issue 3 Pages 217-225
Innocenzo G. Casellaa,*, Tommaso R. I. Cataldia, Antonio Guerrieria and Elio Desimonib

Abstract: A vitreous C electrode (0.125 cm2 area) was coated with a polyaniline (PANI) film by galvanostatic polymerization from a solution containing 85 mM aniline in 0.1 M H2SO4 by cycling the potential between -0.1 and 1.1 V (vs. SCE) for five cycles at 50 mV/s. The coated electrode was immersed in 50 mM CuCl2 in 0.1 M H2SO4 for 5 min and then a potential of -0.3 V was applied for 3 min. The Cu-PANI sensor was evaluated for determining amino-acids and polyhydric compounds. Molar response factors for carbohydrates and amino-acids were measured using a FIA system and 0.1 M NaOH as the carrier stream (1 ml/min). A potential of 0.55 V vs. Ag/AgCl was applied to the sensor. A Carbopac PA 1 anion-exchange column (25 cm x 4 mm i.d.) was coupled to the FIA system to analyze carbohydrates and amino-acids. Xylitol, sorbitol, glucosamine, glucose, lactose and sucrose were separated using 0.15 M NaOH as the mobile phase (0.6 ml/min) and the detection limits were 2-6 pmol. Alanine, glycine, lysine methionine and glutamine were separated with 0.1 M NaOH as the mobile phase (0.5 ml/min) and the detection limits were 5-15 pmol. The linear dynamic range was three-four orders of magnitude above the detection limits. The electrode was stable for >=3 h in flowing streams.
Electrode Electrode Amperometry Electrode Ion exchange Sensor Linear dynamic range

"Anion-exchange Chromatography With Electrochemical Detection Of Alditols And Sugars At A Cu2o-carbon Composite Electrode"
J. Chromatogr. A 1997 Volume 773, Issue 1-2 Pages 115-121
Tommaso R. I. Cataldia,*, Diego Centonzea, Innocenzo G. Casellaa and Elio Desimonib

Abstract: An anion-exchange column coupled with an amperometric sensor was used for the quantitative analysis of alditols and simple sugars. The sensing electrode is composed of cuprous oxide dispersed in a graphite powder-polyethylene composite matrix. The resulting Cu2O-carbon composite electrode is stable in alkaline media and possesses good sensitivity, wide linear dynamic ranges and low detection limits for alditols, mono- and disaccharides. Alditols and carbohydrates are weakly ionizable compounds, so an anion-exchange column was employed for their chromatographic separation with an alkaline eluent. The separation problems due to the presence of low but uncontrolled amounts of carbonate in the alkaline mobile phase have been largely solved by the addition of Ca2+ or Ba2+ at a millimolar level and the consequent formation of carbonate insoluble salts. Using this strategy, the alkaline eluent provides improved separations without compromising the column's lifetime, electrode performance and chromatographic system. Under the optimal operating conditions, the detection limits of D-sorbitol, D-mannitol and D-glucose were 50, 40 and 80 pmol, respectively, with a linear concentration range up to 5 mM. Examples of applications, which include the separation and detection of D-sorbitol, D-mannitol and common sugars present in food samples, are illustrated. 35 References
Food Amperometry Electrode Electrode Ion exchange Optimization

"Model System For A Fluorimetric Biosensor Using Permeabilized Zymomonas Mobilis Or Enzymes With Protein-confined Dinucleotides"
Biotechnol. Bioeng. 1993 Volume 42, Issue 3 Pages 387-393
O. Thordsen, S. J. Lee, A. Degelau, T. Scheper *, H. Loos, B. Rehr, H. Sahm

Abstract: A biosensor for the determination of glucose, fructose, gluconolactone and sorbitol is described. The sensor used either permeabilized Zymomonas mobilis or glucose - fructose oxidoreductase isolated from Z. mobilis. The sensing element was confined to a small measuring chamber fitted with a membrane. This was incorporated into a FIA system. The principle of the system was that the NADP(H) cofactor molecule, which is confined in a protein complex, would be oxidized or reduced during enzymatic reactions, and could be made to undergo fluorescence by excitation at 360 nm (measurement at 450 nm). Using this sensor, changes in fluoresence intensity were related to substrate concentration and the range of sensitivity found to be from 0.001 to 100 g L-1 of analyte. The system was shown to be capable of monitoring bioprocesses by using it to determine the relevant analytes in samples from a Pseudomonas pseudoflava cultivation.
Fermentation broth Fluorescence Sensor Enzyme