University of North Florida
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Stuart Chalk, Ph.D.
Department of Chemistry
University of North Florida
Phone: 1-904-620-1938
Fax: 1-904-620-3535
Email: schalk@unf.edu
Website: @unf

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Progesterone

  • IUPAC Name: (8S,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
  • Molecular Formula: C21H30O2
  • CAS Registry Number: 57-83-0
  • InChI: InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1
  • InChI Key: RJKFOVLPORLFTN-LEKSSAKUSA-N

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Citations 2

"Flow Injection Chemiluminometric Analysis Of Some Steroids By Their Sensitizing Effect On The Bromate-sulfite Reaction"
Anal. Chim. Acta 1990 Volume 239, Issue 2 Pages 195-202
Aristotelis B. Syropoulos, Evangelos G. Sarantonis and Antony C. Calorkerinos

Abstract: The solution of cortisone (I), hydrocortisone, corticosterone, testosterone (II) or progesterone (III) were injected into 2 mM NaBrO3 in 20 mM H2SO4 at 1.5 mL min-1. After mixing with 0.5 mM SO32- the luminescence was measured with a photomultiplier. The responses were rectilinear between 0.5 and 5 to 6 µg mL-1 except for I which was from 0.5 to 20.0 µg mL-1, with limits of detection between 0.1 and 0.4 µg mL-1. The coefficient of variation (n = 6) for 0.5 and 4.0 µg mL-1 of III were 2.3 and 0.5%, respectively, which were typical for all the steroids. Recoveries of II from various excipients were between 95.8 and 104.0%.
Chemiluminescence Sensitivity Detection limit Indirect

"Comparison Of Online And Offline Liquid Chromatography - Nuclear Magnetic Resonance Spectrometry For Analysis Of Steroid Mixtures"
Anal. Chem. 1983 Volume 55, Issue 9 Pages 1611-1614
Joachim Buddrus and Helmut Herzog

Abstract: The advantages and disadvantages of the combined technique in online (continuous-flow) and offline (batch) analysis are discussed. A mixture of progesterone, dehydroepiandrosterone and testosterone in CHCl3 was separated by HPLC on a silica gel column (preconditioned with mobile phase). The mobile phase was 99% C1HCl3, and the fractions obtained were examined by NMR techniques. The equipment for the online method for 1H was as previously described (Organic Magnetic Resonance, 1980, 13, 153). In the offline technique, a 0.5 mL aliquot of each fraction was collected in a NMR tube. The main problem in both techniques is interference with the NMR spectrum by the mobile phase.
HPLC Nuclear magnetic resonance Interferences