University of North Florida
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Stuart Chalk, Ph.D.
Department of Chemistry
University of North Florida
Phone: 1-904-620-1938
Fax: 1-904-620-3535
Email: schalk@unf.edu
Website: @unf

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Phenylephrine

  • IUPAC Name: 3-[(1R)-1-hydroxy-2-(methylamino)ethyl]phenol
  • Molecular Formula: C9H13NO2
  • CAS Registry Number: 59-42-7
  • InChI: InChI=1S/C9H13NO2/c1-10-6-9(12)7-3-2-4-8(11)5-7/h2-5,9-12H,6H2,1H3/t9-/m0/s1
  • InChI Key: SONNWYBIRXJNDC-VIFPVBQESA-N

@ ChemSpider@ NIST@ PubChem

Citations 3

"Application Of A Photodiode Array Detector To Multicomponent Determination By Flow Injection Analysis"
Analyst 1987 Volume 112, Issue 5 Pages 619-622
Marcelo Blanco, Jordi Gené, Hortensia Iturriaga and Santiago Maspoch

Abstract: The simultaneous determination of compounds in two-, three- and four-component mixtures with completely overlapping spectra (e.g., etafedrine, phenylephrine, doxylamine and theophylline) was achieved by flow injection analysis with a diode-array spectrophotometric detection system. The effect of wavelength range and mode of spectral selection was studied. The absorbance spectrum of each solution was recorded 10.7 s after sample injection with an integration time of 0.4 s. The method was applied in the determination of the four active components in Nethaprin tablets, with use of third-derivative spectra in the range 214 to 290 nm.
Pharmaceutical Spectrophotometry Multicomponent Simultaneous analysis

"Simultaneous Determination Of Phenylephrine Hydrochloride And Pheniramine Maleate In Nasal Spray By Solvent Extraction Flow Injection Analysis Using Two Porous-membrane Phase Separators And One Photometric Detector"
Anal. Chem. 1986 Volume 58, Issue 13 Pages 2727-2731
Charles A. Lucy and Frederick F. Cantwell

Abstract: Sample spray was injected at 2-min intervals into water as the carrier stream. Interfering thimerosal, maleate and benzalkonium ion species were removed by passage through beds (length 10 mm) of Amberlyst A-26 macroporous anion-exchange resin (100 to 140 mesh), and, after the addition of 0.2 M NaOH, A15 cation-exchange resin. Following quantitative extraction at pH 13 of pheniramine maleate into CHCl3 via segmented flow, a portion of the CHCl3 phase was separated by a porous PTFE membrane and was directed to the sample flow cell of the spectrophotometric detector. A portion of the aqueous phase, containing phenylephrine, was separated by a paper membrane located further downstream in the segmented flow and was directed to the reference flow cell. Absorbances were measured at 258.3 nm. The spectrophotometer was modified to allow electronic switching of the sample/reference designation of its two flow cells. The precision and accuracy of the technique were 1 to 2%.
Pharmaceutical Clinical analysis Spectrophotometry Sample preparation Interferences Phase separator Teflon membrane Solvent extraction

"Individual And Simultaneous Determination Of Ephedrine And Phenylephrine By The Use Of Kinetic Methodology"
Fresenius J. Anal. Chem. 1994 Volume 349, Issue 12 Pages 824-828
B. Gala, A. Gómez-Hens and D. Pérez-Bendito

Abstract: A 0.1 mL portion of 0.2 mM NaIO4 and 0.5 mL 1 M KHCO3 were added to a solution of ephedrine (I) and phenylephrine (II) (140 µg/ml of I and or II in a final volume of 10 ml); after 5 min 0.75 mL 0.4 mM NaAsO2 was added and the mixture diluted to 10 mL (Solution A). One of the two 2 mL reservoir syringes of a stopped-flow module was filled with a solution containing 0.8 mM HCl, 1.2 mM 2-methylbenzothiazole-2-one hydrazone and a volume of A containing aldehydes corresponding to 0.7-70 µg/ml of I or II. The other was filled with a solution that contained 0.14 mM FeCl3 and 0.64 mM sulfamic acid. A 0.15 mL portion from each was transferred to a mixing chamber at 50°C. Absorbance was measured at 620 nm for 2 min and data processed by linear regression program. Reaction rates were measured from 30-90 s after the start of the reaction. Calibration graphs were linear for 0.7-70 µg/ml of I and 1.2-70 µg/ml of II, respectively. The mean recovery of I was 103.2% and synthetic mixtures containing I/II ratios between 3:1 and 1:5 were resolved.
Spectrophotometry Stopped-flow Heated reaction Kinetic Simultaneous analysis