University of North Florida
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Stuart Chalk, Ph.D.
Department of Chemistry
University of North Florida
Phone: 1-904-620-1938
Fax: 1-904-620-3535
Email: schalk@unf.edu
Website: @unf

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Nicotinic acid

  • IUPAC Name: pyridine-3-carboxylic acid
  • Molecular Formula: C6H5NO2
  • CAS Registry Number: 59-67-6
  • InChI: InChI=1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)
  • InChI Key: PVNIIMVLHYAWGP-UHFFFAOYSA-N

@ ChemSpider@ NIST@ PubChem

Citations 5

"Flow Injection Determination Of Drugs By Specific Detection Of Carboxylic Acids"
Analyst 1988 Volume 113, Issue 11 Pages 1673-1675
Toshifumi Takeuchi, Yozo Kabasawa, Rikizo Horikawa and Takenori Tanimura

Abstract: A variety of carboxylic acid drugs were determined. A portion, containing ~0.25 mmol of drug, of the powder obtained from 20 tablets or capsules was extracted with ethanol or water, the extract was filtered, and the filtrate was analyzed in a flow injection system in which it was treated with 0.02 M 2-nitrophenylhydrazine in 0.2 M HCl and 0.05 M 1-ethyl-3-(3-dimethylaminopropyl)carbodi-imide in ethanolic 4% pyridine in the first reaction coil (10 m x 0.5 mm) at 60°C and with 1.5 M NaOH in a second coil of the same dimensions and temperature After cooling to 30°C in a third coil (1 m x 0.5 mm) the absorbance was measured at 540 nm. Satisfactory results were obtained for aspirin, ibuprofen, dehydrocholic acid, nicotinic acid and tranexamic acid, with recoveries of 99.9 to 103.4% and coefficient of variation (n = 10) of 0.8%.
Pharmaceutical Pharmaceutical Spectrophotometry Heated reaction

"Surface Enhanced Raman Spectroscopy As A Molecular Specific Detection System In Aqueous Flow-through Systems"
Analyst 1998 Volume 123, Issue 5 Pages 1057-1060
N. Weißenbacher, B. Lendl, J. Frank, H. D. Wanzenböck and R. Kellner

Abstract: Surface enhanced Raman scattering (SERS) is proposed as a mol. specific technique for direct measurements of organic molecules in aqueous solutions An FT-Raman spectrometer was interfaced with a flow injection manifold operated in the stopped-flow mode enabling reproducible collection of SERS spectra due to the automation of the anal. procedure. For SERS a solid state substrate placed in a newly developed flow-cell was used. Multiple measurements on one single SERS substrate were achieved by rinsing the substrate with reagents such as 3 M KCl or 0.1 M NaOH solutions prior to the next measurements to remove retained analytes from the surface of the SERS substrate. This procedure allowed for improved precision as compared with a conventional batch approach. Quant. aspects were studied by establishing a calibration curve for nicotinic acid which was used as a model analyte. A linear dependence of the recorded SERS intensities from the logarithm of the analyte concentration. was obtained throughout the whole studied concentration. range (0.001-0.1 M, correlation coefficient r2 = 0.97). The standard deviation of the method sx0 is 0.122 mM and detection limit 1.7 mM, respectively. The results demonstrate the potential of SERS spectroscopy to be used as a molecular specific detector in aqueous flow systems such as flow injection anal.
Raman Raman Stopped-flow Flowcell Apparatus Method comparison

"High Performance Liquid Chromatographic Determination Of Nicotinic Acid And Nicotinamide In Biological Samples Applying Post-column Derivatization Resulting In Bathmochrome Absorption Shifts"
J. Chromatogr. B 1995 Volume 665, Issue 1 Pages 71-78
J. Stein*, A. Hahn and G. Rehner

Abstract: An ion-pair reversed-phase high performance liquid chromatographic procedure for the rapid separation and sensitive quantitation of nicotinic acid (NA) and nicotinamide (NAM) in biological samples was developed. The vitamers were separated within 10 min on an octadecylsilica column applying a linear gradient of tetrabutylammonium phosphate and methanol. NA and NAM were converted to highly absorbing derivatives by a modified Konig's reaction using a double post-column derivatization arrangement consisting of two pumps and two knitted tubular reactors. The proposed method is highly sensitive and specific and applicable to biological materials as was shown by the analysis of rat intestinal tissue.
Rat HPLC Spectrophotometry Post-column derivatization Knotted reactor

"Bioelectrochemically Accelerated Microbial Conversion Of Nicotinic Acid To 6-hydroxynicotinic Acid On Microorganism-immobilized Column Electrolytic Flow System"
Chem. Lett. 1998 Volume 27, Issue 4 Pages 295-296
Masaki Torimura, Hideto Yoshida, Kenji Kano, Tokuji Ikeda, Toru Nagasawa, and Teruhisa Ueda

Abstract: Nicotinic acid (NA) is efficiently hydroxylated into 6-hydroxynicotinic acid (6HNA) by Pseudomonas fluorescens TN5-immobilized column electrolytic method using K3Fe(CN)6 as an extracellular electron transfer mediator, in which the conversion rate was sufficiently accelerated compared with the aerobic oxidation The NA conversion system was applied to the continuous-prodn. of 6HNA in 100% yield and the abs. determination of NA in flow injection anal.
Spectrophotometry Immobilized bacteria

"Continuous Surface-enhanced Raman-spectroscopy For The Detection Of Trace Organic Pollutants In Aqueous Systems"
J. Mol. Struct. 1997 Volume 410, Issue 1 Pages 539-542
N. Weissenbacher*, B. Lendl, J. Frank, H. D. Wanzenböck, B. Mizaikoff and R. Kellner

Abstract: In Raman spectroscopy, detection limits for organic pollutants in water can be lowered by several orders of magnitude when surface enhanced techniques are applied. In this work a continuous analytical device based on flow injection analysis using SERS detection is proposed. This system was tested with model analytes such as pyridine and nicotinic acid as well as several pesticides (carbendazim, metazachlorine). (C) 1997 Elsevier Science B.V. 22 References
Raman