Contact Info
Stuart Chalk, Ph.D.
Department of Chemistry
University of North Florida
Phone: 1-904-620-1938
Fax: 1-904-620-3535
Email: schalk@unf.edu
Website: @unf
Felodipine
- IUPAC Name: 5-O-ethyl 3-O-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
- Molecular Formula: C18H19Cl2NO4
- CAS Registry Number: 72509-76-3
- InChI: InChI=1S/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8,15,21H,5H2,1-4H3
- InChI Key: RZTAMFZIAATZDJ-UHFFFAOYSA-N
Citations 1
"Flow Injection Extraction Applied To Dissolution Rate Studies Of Felodipine Tablets"
J. Pharm. Biomed. Anal.
1989 Volume 7, Issue 4 Pages 421-431
L. Nord*, M. Sundgren and A. Torstensson
Abstract:
A flow injection analysis (FIA) extraction method has been developed for the analysis of felodipine tablets in connection with dissolution rate testing. The water-soluble oxidation product of felodipine, a pyridine derivative, was extracted into chloroform and measured at 275 nm spectrophotometrically. The FIA-extraction method has been compared with the present liquid chromatographic (LC) method. The sampling rate for the FIA-extraction (60 samples h-1) is 5 times higher than for the LC method. The FIA-extraction method has a standard deviation of 1% for both standards and samples which is the same as for the LC method.
Pharmaceutical
Sample preparation
Spectrophotometry
Extraction
Dissolution rate
Method comparison
Organic phase detection