University of North Florida
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Stuart Chalk, Ph.D.
Department of Chemistry
University of North Florida
Phone: 1-904-620-1938
Fax: 1-904-620-3535
Email: schalk@unf.edu
Website: @unf

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Antibiotics

@ ChemSpider@ NIST@ PubChem

Citations 3

"Flow Injection Determination Of Tylosin In Fermentation Broth"
Anal. Chim. Acta 1993 Volume 281, Issue 2 Pages 243-247
Frank L. Neely*

Abstract: Fermentation broth was extracted with isopropyl acetate. A portion (5 µL) of the solution was injected into the reagent stream (3 ml/min) of cis-aconitic anhydride in acetic anhydride/isopropyl acetate (1:1). The reaction took place at 45°C in a stainless-steel tube reactor and the absorbance of the red salt formed was measured at 525 nm. The calibration graph was linear for 0.11-2.2 mM tylosin (I). The linear range was extended to 11 mM I, by changing the wavelength to 560 nm. Recovery was 96.6-106.1% for fermentation broth spiked with a concentration. aqueous solution of I over the domain 50-500% of initial I concentration. The method may be applied in the determination of a variety of antibiotics possessing a tertiary amine moiety.
Fermentation broth Spectrophotometry Sample preparation Extraction Reactor

"Solid-surface Photoluminescence And Flow Analysis: A Happy Marriage"
Anal. Chim. Acta 1993 Volume 283, Issue 1 Pages 367-378
Alfredo Sanz-Medel*

Abstract: The basic principle of photoluminescence of an organic molecule is described, and methods of conventional photoluminescence at solid surfaces are reviewed. The use of optical sensing at solid surfaces for detection in flow techniques is discussed, with particular reference to photoluminescence and means of achieving this at room temperature Applications of solid-surface photoluminescence in flow systems are outlined, including the determination of cations, anions and gases, the detection of O2 in enzymatic reactions, and the determination of antibiotics. (49 references).
Luminescence Photochemistry Review

"Pre- And Post-column Derivatization Chemistry In Conjunction With HPLC For Pharmaceutical Analysis"
J. Chromatogr. Sci. 1988 Volume 26, Issue 8 Pages 362-371
Danielson, N.D.;Targove, M.A.;Miller, B.E.

Abstract: A review is presented, with 248 references, which covers derivatization - HPLC analysis of, e.g., alkaloids, amines, antibiotics, barbiturates and steroids. Application to biological materials is included.
Biological material Pharmaceutical HPLC Review Post-column derivatization